Low Vitamin B6 Intake Associated with Parkinson's Risk

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 29 August 2010 - 07:04 PM

Low Vitamin B6 Intake Associated with Parkinson's Risk
2010-08-27 - British Journal of Nutrition

http://www.npicenter...=28675&zoneid=2

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine.



However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.

http://www.npicenter...=28675&zoneid=2

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Kathrynne Holden, MS

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#2 Beachdog

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30-September 09 LocationCape Cod Massachusetts Posted 30 August 2010 - 09:21 AM

I'm not a researcher but this study looks fuzzy. Looking at only one month's worth of diets for PWPD and normal people, adjusting for "nonconfounding" factors, and reaching a conclusion feels like a stretch. IMHO at least

Rich

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#3 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 31 August 2010 - 05:57 PM

You are right on target, this is by no means conclusive. However, there have been a number of studies associating various B vitamins with various aspects of PD, and I am very glad whenever researchers elaborate on some aspect. Trouble is, they so often present fascinating data but then no one ever follows up on it. Drat!

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Kathrynne Holden, MS

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#4 teokimhoe

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03-March 07 LocationMalaysia Posted 02 September 2010 - 07:38 AM

Kathrynne Holden, MS, on 31 August 2010 - 05:57 PM, said:

You are right on target, this is by no means conclusive. However, there have been a number of studies associating various B vitamins with various aspects of PD, and I am very glad whenever researchers elaborate on some aspect. Trouble is, they so often present fascinating data but then no one ever follows up on it. Drat!



I have once been suffered by taking more than 6 mg Vit B6 with parkinson medication Sinemet, Requip and Jumex i.e. low blood pressure, dizzinness and T.I.A (mini stroke ) still yet to be confirmed.

Kindly elaborate

Regards

TEIKIMHOE

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families
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#5 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 03 September 2010 - 06:02 PM

teokimhoe, on 02 September 2010 - 07:38 AM, said:

I have once been suffered by taking more than 6 mg Vit B6 with parkinson medication Sinemet, Requip and Jumex i.e. low blood pressure, dizzinness and T.I.A (mini stroke ) still yet to be confirmed.

Kindly elaborate

Regards

TEIKIMHOE



Best regards,

Kathrynne Holden, MS

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#6 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 03 September 2010 - 06:08 PM

I am not aware that use of B6 would be implicated in low blood pressure, dizziness, or stroke, particularly at that relatively low dose. Larger doses of B6 may interfere with the absorption of levodopa, but generally with use of Sinemet, most individuals can take 10-15 mg, sometimes as much as 20-25 mg of B6 without interference.

I would consult with your personal physician. You need to learn whether or not a stroke took place. Apart from that, hypotension (low blood pressure) can occur with PD independently of dietary supplements and your doctor may want to prescribe medication to help correct it.

Best regards,

Kathrynne Holden, MS

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nutrition, vitamin and parkinson's by Dr.Kathrynne

nutrition,vitamin and parkinson’s
Nutrition are importance for those with Parkinson Disease. Nutrition won’t cure PD or slow its progression.

There are vitamins and mineral at certain level are harmful for Parkinson’s Patients especially Folic Acid, Chromium,Copper, Ferritin,Magnessium,Selerium,Zinc and vitamin B6.

Therefore doctor who prescribes vitamins for PD has to routinely monitor them. Some of them may be good for general health and well being but not have been definitively proven to help PD. CoQ10 and creatine are currently under study. We will know about these two drugs very soon. But for the rest, they have not been proven.

I have once blood test to measure my vitamin level in Add Life Anti Aging Bangkok. I have suffered low blood pressure by taking some of the vitamins. As the result I admitted to Hospital. I have T.I.A (mini stroke) still yet to answer.

Regards

TeoKimHoe

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families





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#2 Kathrynne Holden, MS
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Posted Today, 06:31 PM

Thank you for your comments. I would be interested in seeing the studies on these supplements with relation to low blood pressure, if you care to send them.

Best regards,

Kathrynne Holden, MS

–

Living with PD by Dr Kathrynne

Dear Doctor,


I feel proud I come out with the book Heroteo- the chronicles of a parkinson's fighter.

while living with PD . The proceed of sales to the Malayan parkinson society.My objective is to raise

the awareness the disease to the public and support group. The accomplishments for me are demonstrated to the sufferers that they are not alone.

As Asian are shy with the disease they prefer to stay home. They do not live with quality of life.

They do not shopping, travelling, eating what western do. They have poor knowledge of PD.

As Parkinson's have emotional and non emotional disorders and there are so far no cure treatment they have to learn how to slow down the disease by taking actively in public and joining forums to enlighten their knowledge of PD to slow down the disease.

TEOKIMHOE

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families
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#2 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted Yesterday, 06:23 PM

Mr. Teo, I certainly wish you well in your endeavors, and in your admirable goal to raise awareness of PD in Malaysia. I hope your book will help to achieve this very worthy objective, and that others will be inspired by your example.

Best regards,

Kathrynne Holden, MS

--

For a Parkinson Tip of the Day visit:

nutrition, vitamin and parkinson's by Dr.Kathrynne

nutrition,vitamin and parkinson's
Nutrition are importance for those with Parkinson Disease. Nutrition won't cure PD or slow its progression.

There are vitamins and mineral at certain level are harmful for Parkinson's Patients especially Folic Acid, Chromium,Copper, Ferritin,Magnessium,Selerium,Zinc and vitamin B6.


Therefore doctor who prescribes vitamins for PD has to routinely monitor them. Some of them may be good for general health and well being but not have been definitively proven to help PD. CoQ10 and creatine are currently under study. We will know about these two drugs very soon. But for the rest, they have not been proven.

I have once blood test to measure my vitamin level in Add Life Anti Aging Bangkok. I have suffered low blood pressure by taking some of the vitamins. As the result I admitted to Hospital. I have T.I.A (mini stroke) still yet to answer.

Regards

TeoKimHoe

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families
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#2 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted Today, 06:31 PM

Thank you for your comments. I would be interested in seeing the studies on these supplements with relation to low blood pressure, if you care to send them.

Best regards,

Kathrynne Holden, MS

--

For a Parkinson Tip of the Day visit:

knowledge is power

Dear Doctors,

Do any PD medications slow down the disease?
I started with Q 10 when I diagnosed as Parkinson's last five years old.

It is not the parkinson's medication but a supplements as some doctors prescribe for an early parkinson's patient.

I take Sinemet regular on the third years when my movement is slow. I increase Requip medication and improve my movement after six months. Besides I take vitamin and supplements daily as I do blood test on my vitamin and mineral level twice in a year.

Diet, nutrition and exercises are important too .

I wish to thank NPF Forum and medical Panel that I learn and share with the readers on how to battle the diseases.

All are in one to slow down the parkinson's. Discipline, perservation, consistance on yourself are the power to battle the parkinson's as It is a chronic disease and expensive for treatment

TEOKIMHOE

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#2 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted Today, 06:16 PM

Indeed knowledge is power. So far as I am aware, no PD medications have been definitely proven to slow the progression of disease. There are studies underway on various supplements, including CoQ10, and when we have the results, we will certainly post them to the forums.

Best regards,

Kathrynne Holden, MS

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urination

I have experienced a lack control as far as urination’s concern. Firstly, when I am in the midst of urinating, I am unable to hold back or stop halfway through. Secondly, when I feel the need to urinate I must go to the toilet immediately. I will not be able to hold back at all. I have seen Urologist and was told my PSA is normal though I have slight enlarged prostate gland. My medication: one dose Harnal 400 mcg taken before bedtime daily.

Questions:

Any side effect with parkinson's medication Sinemet, Jumax and requip by causing low blood pressure and dizzinness?

Any alternative

Regards

TEOKIMHOE

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families
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#2 Dr. Okun

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19-January 07 LocationUniversity of Florida Posted Today, 06:30 AM

Many PD patients have these symptoms and sometimes they are PD, sometimes urological, and sometimes anxiety. I will post for comments from others.

Michael S. Okun, M.D.

CPK Blood Test

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03-March 07 LocationMalaysia Posted Today, 03:55 AM

Dear Dr.Okun,

My cardiac enzymes CPK is 288 level.

What is the normal/higher CPK level?

Is anxiety and depression affected your higher level of CPK?

Kindly elaborate

Regards

TEOKIMHOE

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#2 Dr. Okun

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19-January 07 LocationUniversity of Florida Posted Today, 06:32 AM

I will post for you as this is not my area of expertise.

The CK must be interpreted by an internist or cardiologist and there are fractions that indicate the type of muscle breakdown. In many cases elevations of a few hundred are normal, but you need to see an internist or cardiologist to be sure. When CK's get into the thousands it can be dangerous, and in some cases it heralds muscle disease. I will post for you.

Michael S. Okun, M.D.

Dear Dr.Okun,

What is the cause of CPK at high level?

How it to be prevented?

The internist or cardiologist still yet to answer.

Regards


TEOKIMHOE

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#4 Dr. Okun

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19-January 07 LocationUniversity of Florida Posted Today, 06:18 AM

Here is a link to medline plus where the enzyme test is explained.

http://www.nlm.nih.g...icle/003503.htm

Michael S. Okun, M.D.


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