Minirin works by increasing the amount of water that is reabsorbed by your kidneys.
When it is given in higher doses, it can also raise your blood pressure.
Because the medication is causing your kidneys to reabsorb water, this can lead to your sodium levels to drop.
If your sodium levels drop too much, this can make you very ill. At sodium levels of 120, you can feel nauseated, more short of breath, dizzy, fatigued and be vomiting.
So, much of your symptoms were likely due to your low sodium, which was due to the minirin.
Wednesday, October 6, 2010
Medical
Ask a Medical Question, Get an Answer AS
why Minirin caused side effects vomiting,short of heart breath,tired and sodium at abnormal level at 120
Your Expert needs more information
From Dr. Abby
Tuesday, October 05, 2010 6:52 PM EST
Hello,
First, why were you on the medication?
to increase my low blood level as there are at negative level upright and sit down. short of breath, tir
Expert
You have received an Answer!
From Dr. Abby
Tuesday, October 05, 2010 7:13 PM EST
Ok, thank you for clarifying,
Minirin works by increasing the amount of water that is reabsorbed by your kidneys.
When it is given in higher doses, it can also raise your blood pressure.
Because the medication is causing your kidneys to reabsorb water, this can lead to your sodium levels to drop.
If your sodium levels drop too much, this can make you very ill. At sodium levels of 120, you can feel nauseated, more short of breath, dizzy, fatigued and be vomiting.
So, much of your symptoms were likely due to your low sodium, which was due to the minirin.
Feel free to ask any follow up questions,
Dr Abby
Ask a Medical Question, Get an Answer AS
why Minirin caused side effects vomiting,short of heart breath,tired and sodium at abnormal level at 120
Your Expert needs more information
From Dr. Abby
Tuesday, October 05, 2010 6:52 PM EST
Hello,
First, why were you on the medication?
to increase my low blood level as there are at negative level upright and sit down. short of breath, tir
Expert
You have received an Answer!
From Dr. Abby
Tuesday, October 05, 2010 7:13 PM EST
Ok, thank you for clarifying,
Minirin works by increasing the amount of water that is reabsorbed by your kidneys.
When it is given in higher doses, it can also raise your blood pressure.
Because the medication is causing your kidneys to reabsorb water, this can lead to your sodium levels to drop.
If your sodium levels drop too much, this can make you very ill. At sodium levels of 120, you can feel nauseated, more short of breath, dizzy, fatigued and be vomiting.
So, much of your symptoms were likely due to your low sodium, which was due to the minirin.
Feel free to ask any follow up questions,
Dr Abby
Monday, October 4, 2010
defination of cure of PD
The word “cure” is often used as the stated, or assumed, ultimate goal of Parkinson’s disease research. The more I think about it, the less sure I am just what constitutes a “cure” in connection to PD. A big part of the difficulty of coming up with a definition may be because it’s tough to separate effects of the disease itself, medications and the simple process of aging.
So …. can you offer a working definition of what a “cure” is in relation to PD?
Great question.
A cure is usually when the disease has been completely eradicated from an individual patient.
Symptomatic therapy is when a therapy helps improve individual symptoms.
Disease modification is when a therapy improves the course or slows the course of the disease.
Hope that helps.
Michael S. Okun, M.D.
So …. can you offer a working definition of what a “cure” is in relation to PD?
Great question.
A cure is usually when the disease has been completely eradicated from an individual patient.
Symptomatic therapy is when a therapy helps improve individual symptoms.
Disease modification is when a therapy improves the course or slows the course of the disease.
Hope that helps.
Michael S. Okun, M.D.
new drug for hypotension
Advanced Member
Group:
Ask the Doctor Moderators Posts:
732 Joined:
19-January 07 LocationUniversity of Florida Posted Today, 01:08 PM
Dear forum members,
Forty percent or more of PD patients suffer from orthostatic hypotension (dizziness when standing, passing out, etc.). Dr. Lowe from the Mayo clinic presented some very promising results at the World Congress for PD in Scotland last week.
There is a drug called droxidopa in trials; which is a hydroxylated form of levodopa.
Though this may be above some heads I want to mention the two mechanisms of action:
1- post-ganglionic alpha 1 receptor is stimulated on aterioles
2- there seems to be repletion of adrenergic terminals with the neurochemical norepinephrine in both the peripheral nervous system and the central nervous system
The preliminary data is yet to be released but what was presented was very promising.
Midodrine which is another drug available to treat this condition has a greater effect on the blood pressure when lying down. Droxidopa has a greater effect when standing which is potentially more clinically important to patients.
The droxidopa seems to be well tolerated.
We await to hear about the 20-25% of patients who were excluded from the studies because the drug didn't seem to be effective enough in the dose titration part of the study,
We will keep you posted as more data becomes available.
Michael S. Okun, M.D.
Group:
Ask the Doctor Moderators Posts:
732 Joined:
19-January 07 LocationUniversity of Florida Posted Today, 01:08 PM
Dear forum members,
Forty percent or more of PD patients suffer from orthostatic hypotension (dizziness when standing, passing out, etc.). Dr. Lowe from the Mayo clinic presented some very promising results at the World Congress for PD in Scotland last week.
There is a drug called droxidopa in trials; which is a hydroxylated form of levodopa.
Though this may be above some heads I want to mention the two mechanisms of action:
1- post-ganglionic alpha 1 receptor is stimulated on aterioles
2- there seems to be repletion of adrenergic terminals with the neurochemical norepinephrine in both the peripheral nervous system and the central nervous system
The preliminary data is yet to be released but what was presented was very promising.
Midodrine which is another drug available to treat this condition has a greater effect on the blood pressure when lying down. Droxidopa has a greater effect when standing which is potentially more clinically important to patients.
The droxidopa seems to be well tolerated.
We await to hear about the 20-25% of patients who were excluded from the studies because the drug didn't seem to be effective enough in the dose titration part of the study,
We will keep you posted as more data becomes available.
Michael S. Okun, M.D.
parkinson and blood pressure
Posted: Fri Apr 18, 2008 6:13 am Post subject: Parkinson’s medication and Blood pressure
Dear Doctor, I am taking Lavodopa,Carbidopa and dopamin agonist for two year Close monitoring is required for people with certain medical condition. After I have a minor stroke (T.I.A) recently, I experience two different blood pressure i.e. decreased blood pressure when rising from a seated position or lie-down on bed after lengths of times. I feel dizziness on standing,headache or fainting My mouth run dry and thirsty Insomnia, anxiey, and fatigue, malaise Kindly elaborate Thanks TEOKIMHOE
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 20, 2008 7:05 pm Post subject:
There are many potential reasons for orthostasis or dizziness on standing up. Dopamine agonists and TCA antidepressants can have this as a side effect. Alternatively it could be an issue of hydration and you may need 6-8 glasses of water a day and compression stockings. Occassionally drugs like midodrine, florinef and mestinon are needed to keep the BP up._________________Michael S. Okun, M.D.
Back to top
Anonymous
Posted: Sun Apr 20, 2008 9:47 pm Post subject:
Normal blood pressure is regulated by specific reflexes in the nervous system. Parkinson’s disease can impair this reflex mechanism and result in lowered blood pressure.Low blood pressure usually presents itself as side-effect of anti parkinson’s medications. Levodopa-carbidopa, dopamine agonists and other antidepressions and sleeping medications may potentiate a hypotensive event Source: Linda P.Miller,R.N.Med Posted by Hero Teo at 10
Back to top
Anonymous
Posted: Sat Apr 26, 2008 2:16 am Post subject: dizzinness and parkinson’s medication
I am glad that your dizziness has subsided. Dizziness is a very common symptom among Parkinson’s patients. It needs extensive work-up, e.g. blood pressure, heart rhythm, blood tests (diabetes) and even brain scan. A common cause of dizziness among Parkinson’s patients is the medications for PD, which can lower the blood pressure. Commonly, I use fludrocortisone to elevate the blood pressure. Parkinson’s patients need regular blood pressure monitoring (lying position and standing). Dr Chew Nee Kong, Kuala Lumpur.
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 27, 2008 8:48 am Post subject:
Thanks for the nice comment._________________Michael S. Okun, M.D.
As dopamine agonists Ropinirole (Requip) can have this as a side effect (dizzinness at all time) I stop taking them i.e 6 mg Requip daily. I substitute Lavodopa 25/100 Sinemet 2 1/2 dosages with 2 dosage Jumax 5mg daily immediately.
Dear Doctor, I am taking Lavodopa,Carbidopa and dopamin agonist for two year Close monitoring is required for people with certain medical condition. After I have a minor stroke (T.I.A) recently, I experience two different blood pressure i.e. decreased blood pressure when rising from a seated position or lie-down on bed after lengths of times. I feel dizziness on standing,headache or fainting My mouth run dry and thirsty Insomnia, anxiey, and fatigue, malaise Kindly elaborate Thanks TEOKIMHOE
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 20, 2008 7:05 pm Post subject:
There are many potential reasons for orthostasis or dizziness on standing up. Dopamine agonists and TCA antidepressants can have this as a side effect. Alternatively it could be an issue of hydration and you may need 6-8 glasses of water a day and compression stockings. Occassionally drugs like midodrine, florinef and mestinon are needed to keep the BP up._________________Michael S. Okun, M.D.
Back to top
Anonymous
Posted: Sun Apr 20, 2008 9:47 pm Post subject:
Normal blood pressure is regulated by specific reflexes in the nervous system. Parkinson’s disease can impair this reflex mechanism and result in lowered blood pressure.Low blood pressure usually presents itself as side-effect of anti parkinson’s medications. Levodopa-carbidopa, dopamine agonists and other antidepressions and sleeping medications may potentiate a hypotensive event Source: Linda P.Miller,R.N.Med Posted by Hero Teo at 10
Back to top
Anonymous
Posted: Sat Apr 26, 2008 2:16 am Post subject: dizzinness and parkinson’s medication
I am glad that your dizziness has subsided. Dizziness is a very common symptom among Parkinson’s patients. It needs extensive work-up, e.g. blood pressure, heart rhythm, blood tests (diabetes) and even brain scan. A common cause of dizziness among Parkinson’s patients is the medications for PD, which can lower the blood pressure. Commonly, I use fludrocortisone to elevate the blood pressure. Parkinson’s patients need regular blood pressure monitoring (lying position and standing). Dr Chew Nee Kong, Kuala Lumpur.
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 27, 2008 8:48 am Post subject:
Thanks for the nice comment._________________Michael S. Okun, M.D.
As dopamine agonists Ropinirole (Requip) can have this as a side effect (dizzinness at all time) I stop taking them i.e 6 mg Requip daily. I substitute Lavodopa 25/100 Sinemet 2 1/2 dosages with 2 dosage Jumax 5mg daily immediately.
florinef
Dear Doctor, I am taking Lavodopa,Carbidopa and dopamin agonist for two year Close monitoring is required for people with certain medical condition. After I have a minor stroke (T.I.A) recently, I experience two different blood pressure i.e. decreased blood pressure when rising from a seated position or lie-down on bed after lengths of times. I feel dizziness on standing,headache or fainting My mouth run dry and thirsty Insomnia, anxiey, and fatigue, malaise Kindly elaborate Thanks TEOKIMHOE
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 20, 2008 7:05 pm Post subject:
There are many potential reasons for orthostasis or dizziness on standing up. Dopamine agonists and TCA antidepressants can have this as a side effect. Alternatively it could be an issue of hydration and you may need 6-8 glasses of water a day and compression stockings. Occassionally drugs like midodrine, florinef and mestinon are needed to keep the BP up._________________Michael S. Okun, M.D.
Back to top
Anonymous
Posted: Sun Apr 20, 2008 9:47 pm Post subject:
Normal blood pressure is regulated by specific reflexes in the nervous system. Parkinson's disease can impair this reflex mechanism and result in lowered blood pressure.Low blood pressure usually presents itself as side-effect of anti parkinson's medications. Levodopa-carbidopa, dopamine agonists and other antidepressions and sleeping medications may potentiate a hypotensive event Source: Linda P.Miller,R.N.Med Posted by Hero Teo at 10
Back to top
Anonymous
Posted: Sat Apr 26, 2008 2:16 am Post subject: dizzinness and parkinson's medication
I am glad that your dizziness has subsided. Dizziness is a very common symptom among Parkinson's patients. It needs extensive work-up, e.g. blood pressure, heart rhythm, blood tests (diabetes) and even brain scan. A common cause of dizziness among Parkinson's patients is the medications for PD, which can lower the blood pressure. Commonly, I use fludrocortisone to elevate the blood pressure. Parkinson's patients need regular blood pressure monitoring (lying position and standing). Dr Chew Nee Kong, Kuala Lumpur.
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 27, 2008 8:48 am Post subject:
Thanks for the nice comment._________________Michael S. Okun, M.D. 4/28/08 by teo Delete
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 20, 2008 7:05 pm Post subject:
There are many potential reasons for orthostasis or dizziness on standing up. Dopamine agonists and TCA antidepressants can have this as a side effect. Alternatively it could be an issue of hydration and you may need 6-8 glasses of water a day and compression stockings. Occassionally drugs like midodrine, florinef and mestinon are needed to keep the BP up._________________Michael S. Okun, M.D.
Back to top
Anonymous
Posted: Sun Apr 20, 2008 9:47 pm Post subject:
Normal blood pressure is regulated by specific reflexes in the nervous system. Parkinson's disease can impair this reflex mechanism and result in lowered blood pressure.Low blood pressure usually presents itself as side-effect of anti parkinson's medications. Levodopa-carbidopa, dopamine agonists and other antidepressions and sleeping medications may potentiate a hypotensive event Source: Linda P.Miller,R.N.Med Posted by Hero Teo at 10
Back to top
Anonymous
Posted: Sat Apr 26, 2008 2:16 am Post subject: dizzinness and parkinson's medication
I am glad that your dizziness has subsided. Dizziness is a very common symptom among Parkinson's patients. It needs extensive work-up, e.g. blood pressure, heart rhythm, blood tests (diabetes) and even brain scan. A common cause of dizziness among Parkinson's patients is the medications for PD, which can lower the blood pressure. Commonly, I use fludrocortisone to elevate the blood pressure. Parkinson's patients need regular blood pressure monitoring (lying position and standing). Dr Chew Nee Kong, Kuala Lumpur.
Back to top
Dr. OkunJoined: 19 Jan 2007Posts: 251Location: University of Florida
Posted: Sun Apr 27, 2008 8:48 am Post subject:
Thanks for the nice comment._________________Michael S. Okun, M.D. 4/28/08 by teo Delete
Born Parkinson's
I have heard of Parkinson’s Disease. I don’t understand how you get it. I was told you are born with it. Is this true and how do you know if you have it or not?
(anonymous)
Hide Answer
A:
At this time, we really don’t know if one is “born” with Parkinson’s disease
or becomes affected with it as he grows older. One theory suggests that some people are born with fewer dopamine-producing cells (either genetically
or that there is some problem during pregnancy - such as trauma or a virus -
which contributes to being born with fewer dopamine-producing cells). Then,
as the individual ages and naturally loses cells, this person would pass
the 80% dopaminergic neuronal loss that is needed before PD symptoms appear. Other theories suggest some sort of environmental insult causing the drop in
dopamine cells. Unfortunately, we just don’t know yet as these are theories
that must either be proven or disproven via research.
How do you know you have Parkinson’s disease? The best way is to consult a
neurologist who specializes in movement disorders. Neurology, while a
specialty itself, is split into sub-specialties. Parkinson’s disease is a
movement disorder so one who has additional training in movement
disorders, and thus sees primarily patients with such movement disorders, is the best type of physician to consult for a diagnosis.
Tags: Discussion by heroteo
No Comments » | Edit
(anonymous)
Hide Answer
A:
At this time, we really don’t know if one is “born” with Parkinson’s disease
or becomes affected with it as he grows older. One theory suggests that some people are born with fewer dopamine-producing cells (either genetically
or that there is some problem during pregnancy - such as trauma or a virus -
which contributes to being born with fewer dopamine-producing cells). Then,
as the individual ages and naturally loses cells, this person would pass
the 80% dopaminergic neuronal loss that is needed before PD symptoms appear. Other theories suggest some sort of environmental insult causing the drop in
dopamine cells. Unfortunately, we just don’t know yet as these are theories
that must either be proven or disproven via research.
How do you know you have Parkinson’s disease? The best way is to consult a
neurologist who specializes in movement disorders. Neurology, while a
specialty itself, is split into sub-specialties. Parkinson’s disease is a
movement disorder so one who has additional training in movement
disorders, and thus sees primarily patients with such movement disorders, is the best type of physician to consult for a diagnosis.
Tags: Discussion by heroteo
No Comments » | Edit
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