End of Dose Wearing off (EODWO)?

End-of-Dose Wearing Off (EODWO)

As PD is " not going disease' i.e. a slow progression and is different from other disease i.e a self -limited sickness or injury that temporarily impact their lives as inconvenience or comfort.


Patients with Parkinson's disease (PD) who are taking levodopa therapy – the most widely-used may experience the effects of their medication "wearing off" sooner than their health care providers realize.

Wearing off refer the worsening of a parkinson’s disease symptom as its use inability to control parkinson's symptoms over time. It lasts for shorter periods, causing symptoms to re-emerge before the next dose. This phenomenon is known as "wearing off." '

There are almost 50 percent of PD patients receiving levodopa therapy begin to notice that their medication lasts for shorter periods, causing symptoms to re-emerge before the next dose within two to three years.

"Wearing off" is associated with the re-emergence of motor symptoms (e.g. tremor and problems with balance), non-motor symptoms (e.g. anxiety, fatigue, mood changes, and restlessness), and autonomic nervous system dysfunction (e.g. sweating and hypersalivation).

"To date, the frequency of end-of-dose 'wearing off' in a general neurology practice is unknown, and no specific tools exist to aid clinical diagnoses of its signs and symptoms," said Dr. Hauser.

As parkinson’s disease is a movement disorder attention has focussed on problems with movement. However there are symptom are not related with movement they are classified as non-motor symptoms. Some non motor symptoms may interpret as part normal course of disease. However they are bothersome than motor symptoms. Non-motor symptoms can include changes in thoughts and feelings, sensations and sense of well-being and changes in autonomic nervous system functions


Dr. FernandezJoined: 20 Jan 2007Posts: 90
Posted: Sat Aug 09, 2008 4:43 pm Post subject:

thanks!_________________Hubert H. Fernandez