Fatigue

Fatigue may refer to several things in neurological diseases:1.) A generalized lack of energy. 2.) A reduction in the force of individual muscle contractions; overlaps with weakness and atrophy.3.) A psychological state consistent with apathy, inertia, or lack of motivation such as occurs in depression. 4.) Daytime sleepiness caused by poor sleep quality or medication side effects. The management of fatigue is important because it is associated with poor quality of life. There are several targets for treatment. Firstly, sleep quality must be considered. Poor sleep hygiene, anxiety, inability to turn in bed, pain, or breathing difficulties could cause insomnia, leading to daytime sleepiness, irritability, and poor cognitive function. Treatment of these underlying causes may be beneficial. Secondly, poor respiratory function could lead to lack of oxygen for the brain and muscles. Non-invasive ventilation either at night or for periods of the day may be helpful. Thirdly, mood factors such as anxiety and depression can cause psychological feelings of fatigue or inertia, which may respond to drugs or counseling. Finally, a wakefulness-promoting agent such as Modafinil may be prescribed to combat fatigue.