Sunday, September 5, 2010

Low Vitamin B6 Intake Associated with Parkinson's Risk

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 29 August 2010 - 07:04 PM

Low Vitamin B6 Intake Associated with Parkinson's Risk
2010-08-27 - British Journal of Nutrition

http://www.npicenter...=28675&zoneid=2

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine.



However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.

http://www.npicenter...=28675&zoneid=2

Best regards,

Kathrynne Holden, MS

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#2 Beachdog

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30-September 09 LocationCape Cod Massachusetts Posted 30 August 2010 - 09:21 AM

I'm not a researcher but this study looks fuzzy. Looking at only one month's worth of diets for PWPD and normal people, adjusting for "nonconfounding" factors, and reaching a conclusion feels like a stretch. IMHO at least

Rich

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#3 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 31 August 2010 - 05:57 PM

You are right on target, this is by no means conclusive. However, there have been a number of studies associating various B vitamins with various aspects of PD, and I am very glad whenever researchers elaborate on some aspect. Trouble is, they so often present fascinating data but then no one ever follows up on it. Drat!

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Kathrynne Holden, MS

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#4 teokimhoe

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03-March 07 LocationMalaysia Posted 02 September 2010 - 07:38 AM

Kathrynne Holden, MS, on 31 August 2010 - 05:57 PM, said:

You are right on target, this is by no means conclusive. However, there have been a number of studies associating various B vitamins with various aspects of PD, and I am very glad whenever researchers elaborate on some aspect. Trouble is, they so often present fascinating data but then no one ever follows up on it. Drat!



I have once been suffered by taking more than 6 mg Vit B6 with parkinson medication Sinemet, Requip and Jumex i.e. low blood pressure, dizzinness and T.I.A (mini stroke ) still yet to be confirmed.

Kindly elaborate

Regards

TEIKIMHOE

to help the PD patients aware the diseases and encourage to set up support groups to educate the patients and their immediate families
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#5 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 03 September 2010 - 06:02 PM

teokimhoe, on 02 September 2010 - 07:38 AM, said:

I have once been suffered by taking more than 6 mg Vit B6 with parkinson medication Sinemet, Requip and Jumex i.e. low blood pressure, dizzinness and T.I.A (mini stroke ) still yet to be confirmed.

Kindly elaborate

Regards

TEIKIMHOE



Best regards,

Kathrynne Holden, MS

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#6 Kathrynne Holden, MS

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22-January 07 Locationwww.nutritionucanlivewith.com Posted 03 September 2010 - 06:08 PM

I am not aware that use of B6 would be implicated in low blood pressure, dizziness, or stroke, particularly at that relatively low dose. Larger doses of B6 may interfere with the absorption of levodopa, but generally with use of Sinemet, most individuals can take 10-15 mg, sometimes as much as 20-25 mg of B6 without interference.

I would consult with your personal physician. You need to learn whether or not a stroke took place. Apart from that, hypotension (low blood pressure) can occur with PD independently of dietary supplements and your doctor may want to prescribe medication to help correct it.

Best regards,

Kathrynne Holden, MS

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